The influenza virus can kill tens of thousands of Americans in any given year. And this year’s flu season looks like it could be a doozy. Infection rates are higher than they were at this time in recent years, and the strain that hit the southern hemisphere caused record hospitalizations and deaths in Australia. One problem: although the virus strain that scientists selected for the vaccine was the correct one, it mutated once it was put into eggs. Researchers say this kind of situation highlights the need for a universal flu vaccine. We talk with Anthony Fauci, director of the National Institute of Allergy and Infectious Disease.