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A storm heading up the East Coast is coating roads in ice and blanketing regions in snow, and has shut down Washington, D.C., and several other major cities.

The Smithsonian's museums and zoo are now closed due to the government shut down. Tours of historic Washington, D.C. sites have been suspended and the National Gallery of Art is also closed.

Jessica Pegula is seeded No. 6 and Emma Navarro is seeded No. 13. Both women are New York natives.

Drugmakers have brought almost 450 orphan drugs to market and collected rich incentives by doing so. But nearly a third of the medicines aren't new or were repurposed many times for financial gain.

"The business activities of our investors and the rights of our nationals must not be unjustly infringed," a foreign ministry spokesman said after about 300 South Koreans were detained.

To see the speed of demographic change in Texas, look no further than Houston. Over the last few decades — despite crippling humidity, long commutes and a reputation for refineries — the city has become the most diverse in the nation.

Since the 1960s, a bright white light has appeared outside a tiny town in Michigan. Local folklore held it was a ghost. Researchers found a more grounded explanation, but people still flock to see it.

Robert Siegel talks to Maureen Sullivan, senior vice president of strategic services and chief strategy officer for Blue Cross Blue Shield Association, which did the study.

Two rock climbers are close to finishing a hugely ambitious project on El Capitan in the Yosemite Valley — free-climbing the Dawn Wall. They talked to NPR's Melissa Block from the rock face.

Millions are downloading and listening to podcasts. It's the source of original material and growing ad revenue. Apple's iTunes has 1 billion subscribers, and advertisers are seeing dollar signs.